*Correspondence: Jun Xu, [email protected] This article was submitted to Endocrinology of Aging, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
For the bigger picture, tirzepatide's long-term side-effect profile is well-characterized and most issues are concentrated in the first few months
Individual results may vary, and success depends on combining medication with lifestyle modifications including diet and exercise
Simultaneously, insulin tells the liver to stop producing new glucose
This conclusion was further confirmed by a more recent meta-analysis reporting that DPP-4is as a class are neutral in terms of MACEs, all-cause mortality, and HF, although saxagliptin appears associated with an increased risk of hospitalization for HF [152]