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As overall hydrophobicity of TCTP-PTD variants (Kim et al., 2011b) and 1-MIIFR-5 and 9-SHKK-12 residues of TCTP-PTD 13 are favorable for intranasal transduction and solubility, the residues 6-ALI-8 were considered for amino acid residue substitution ( Interestingly, the altered stereochemistry of TCTP-PTD variants was not necessarily favored because both D-TCTP-PTD 13 and D-TCTP-PTD 13M2 did not exhibit enhanced uptake compared to their L-counterparts (Khafagy et al., 2009a)