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Acylated and non-acylated tirzepatide displayed reduced potencies in eliciting GIPR- or GLP-1R-mediated cAMP responses (Supplementary Fig

At the end of the follow-up, a significant improvement was observed in both functional deterioration and overall symptoms

The Vermeulen study found that ALCAR specifically and significantly improved mental fatigue and cognitive concentration (p = 0.015), validating its ability to cross the blood-brain barrier and support neurological function

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