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In fact, most of the patients with TDP-43 pathology do not have mutations in their TARDP gene, and yet have protein accumulations containing phosphorylated TDP-43 13 , and mostly ubiquitinated protein aggregates 10,14,15

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3.1.5 Statistical analysis The primary efficacy outcome was determined by the standardized mean difference (SMD) in validated symptom scale scores between baseline and post-treatment assessments