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Paray BA, et al

10.1038/mp.2015.182 Mol

Several examples have also now emerged suggesting the GH/IGF-1 signaling pathway is relevant to human aging 12 , including the discovery of functional mutations in the IGF-1R gene in individuals with exceptional longevity, resulting in relative IGF-1 resistance 13,14 , and in subjects lacking functional GH receptors (Laron dwarfs) 15

Another study published in the Journal of the American Geriatrics Society found that B12 supplements improved memory and cognitive function in older adults with mild cognitive impairment