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Its rare and mostly avoidable by sticking to the dosing frequency I recommend

Para atletas de alta performance ou com objetivos especficos de emagrecimento, doses mais elevadas, como 2000mg a 3000mg dirias, podem ser consideradas, geralmente divididas em duas ou trs tomadas ao longo do dia

secondly, relative to other organs, the brain has lower levels of ROS scavenging enzymes and thirdly the brain is 60% fat a high proportion of which is unsaturated fatty acids that are highly susceptible to lipid peroxidation

PMID 23674807 Sawka MN, et al

The impact of isolated maternal hypothyroxinaemia on the incidence of large-for-gestational-age infants: the ma'anshan birth cohort study