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The evolving story of incretins (GIP and GLP -1) in metabolic and cardiovascular disease: A pathophysiological update

Risk of new-onset heart failure in patients using sitagliptin: a population-based cohort study

Anecdotally, some people who switched from semaglutide to tirzepatide report that their appetite, which had started returning somewhat on semaglutide, decreased again on tirzepatide

They activate the GLP-1 receptor, which stimulates insulin release, slows gastric emptying, and reduces appetite through effects on the brain