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This indicates that Lira can improve liver fatty acid oxidation in obese mice, reduce liver fat accumulation, and promote hepatic lipolysis by activating the liver SIRT1/PGC-1/PEPCK pathway [67]
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States can opt into discounted GLP1 pricing for Medicaid starting in 2026 under new negotiated pricing, potentially easing cost barriers and encouraging broader adoption
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Expect questions about your medical history, any chronic conditions, medications you take, past attempts at weight loss, and issues that might make tirzepatide unsafe, such as thyroid cancer, severe gastrointestinal disease, or a history of pancreatitis
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