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This interference with glycolysis disrupts Th17 cell differentiation, thereby alleviating rheumatoid arthritis ( + T cells from the peripheral blood of patients with rheumatoid arthritis, catalpol upregulates miR-143-3p, inhibits the abnormal differentiation of Th17 cells, and downregulates glycolysis, thereby regulating the immune balance and exerting anti-inflammatory effects (Shen et al., 2022

The most compelling candidates address multiple mechanisms simultaneously, which is why they show stronger results than compounds targeting a single pathway

And the other thing about the gut microbiome is that it's highly contextual based on other things that you're doing

The antioxidant properties help maintain skin smoothness and may reduce the visible signs of photoaging caused by sun exposure

Although meat and seafood contain high levels of selenium, nuts and grains are also a good source of it [211]