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About OASIS 4 OASIS 4 was a 64-week phase 3 randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of once-daily oral semaglutide 25 mg versus placebo in 307 adults with obesity (BMI 30 kg/m 2 ) or overweight (BMI 27 kg/m 2 ) with one or more weight-related comorbidities

One reason is that fat tissue can produce inflammatory substances that negatively affect the lungs and worsen asthma

The rate and extent of weight loss achieved with Wegovy (around 15% mean weight loss in clinical trials, as noted in NICE TA875) means these metabolic shifts can be quite pronounced

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These are preliminary research findings and not peer reviewed