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Statements Data availability statement The original contributions presented in the study are included in the article, further inquiries can be directed to the corresponding author

GSDME: gasdermin E

Furthermore, while human studies provide critical insights, animal models, particularly rodent models of T2D and obesity, offer valuable opportunities to explore the physiological, metabolic, and molecular responses to allulose in a controlled setting

Published Phase 2 and Phase 3 trials for both molecules enrol as monotherapy (with or without background T2D therapy such as metformin or insulin)

Specific triggers play a significant role like excessive sun exposure, hormonal changes and nutrition