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Engages downstream IGF-1 signaling: When growth hormone increases, the liver produces insulin-like growth factor 1 (IGF-1)

When considering its development, one may expect that initial investigations and clinical trials would focus on its metabolic benefits, gradually revealing its potential for weight loss

One important detail: Louisiana passed Act 276 requiring Medicaid to cover certain weight loss medications, and Wegovy became covered under Louisiana Medicaid in mid-2024 with clinical criteria

After four weeks, the dose is increased to 5 mg once weekly

The EGFR/ErbB3 pathway acts as a compensatory survival mechanism upon c-Met inhibition in human c-Met+ hepatocellular carcinoma