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Importantly, these associations persist after accounting for improvements in glycemic control and body weight, suggesting that the observed neuroprotective signal may not be solely attributable to better metabolic management

Kidney function has also been studied carefully

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A study has revealed that over half of patients experienced severe pain at the outset of, or during, the transition from one biological DMARD (e.g., Adalimumab, Tocilizumab, Rituximab, Abatacept and Anakinra) or targeted synthetic DMARD (e.g., Tofacitinib, Baricitinib and Upadacitinib) to another (Kim et al., 2022b

The good news is that for many, this sensation is temporary and tends to fade as the body acclimates to the dosage