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Figure from Rossing et al NDT 2023 Primary Outcome This was a composite of time of first occurrence of: Onset of kidney failure (persistent eGFR 28 days or initiation of long-term KRT, kidney transplantation) Persistent 50% reduction in eGFR from baseline Death from kidney or CV causes Secondary Outcomes Confirmatory secondary outcomes were analyzed hierarchically

Cost-plus pricing is a method by which the selling price of a product is determined by adding a fixed markup percentage to its cost

For instance, hormone replacement therapy (HRT) or pharmacological agents mimicking estrogen may enhance the protective role of MBOAT1, thereby inhibiting ferroptosis and lipid peroxidation (Liang et al., 2023)

However, as a side effect of taking the medication, many people do experience weight loss