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In HER2-positive breast cancer, overactivation of HER2 upregulates SLC7A11 via the PI3K/AKT/mTOR pathway to increase the antioxidant capacity [85]

The evidence for such a decline is strongest in the brain where glutathione loss is implicated in both Parkinsons disease and in neuronal injury following stroke. In fact, aging can result in a deficiency of glutathione, which can then lead to a number of other issues