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Mechanistically, Tesamorelin binds pituitary GHRH receptors to stimulate the pulsatile release of endogenous growth hormone, which in turn drives hepatic IGF-1 production

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Reductions in BMI, adjusted for duration of treatment, dose, baseline BMI, age and sex, were 17.4% with Ozempic, 17.6% with Wegovy and 15.5% with Mounjaro

Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients Treated With Glp-1 Receptor Agonists: A Multidisciplinary Expert Consensus