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Despite the existing body of reviews describing ferroptosis in the context of diabetes pathophysiology and complications (Yan et al., 2021), there is a notable gap in the literature regarding its specific contribution to DACD

Interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF/MCP-1), chemokines essentially involved in inflammatory and immune reactions

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Therefore, GLP-1RA may induce or exacerbate depressive phenotypes in some susceptible populations, while in others it may exert antidepressant effects by improving metabolism and inflammation