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Improving the diagnostic accuracy for major depressive disorder using machine learning algorithms integrating clinical and near-infrared spectroscopy data

A randomized controlled trial showed that GLP-1RAs prevents the decline of cerebral metabolic rate for glucose (CMRglc) in AD, and GLP-1RAs may increase the expression of glucose transporters (e.g., GLUT1) at the blood-brain barrier (BBB) (Mullins et al., 2019)

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Compared with nonusers, adults taking GLP-1s had a: 17 percent lower risk of venous thromboembolism, or blood clots in the veins 31 percent lower risk of pulmonary embolism, a potentially life-threatening clot that travels to the lungs 21 percent lower risk of going to the emergency department 44 percent lower risk of all-cause mortality (death from any cause) Researchers also observed lower stroke rates among GLP-1 users, although this difference didnt reach statistical significance