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On August 16, 2022, an 8-week storage time was authorized when JYNNEOS is held +2C to +8C after thawing

Oxidative stress activates NUPR1 by both ER stress (METH [79] and H2O2 [80]) and non-ER stress pathways, NUPR1 regulates ferroptosis via iron metabolism, ROS homeostasis, and the GSH/GPX4 pathway [81, 82]

Solutions adjusted to different pH values as well as solutions simulating the chemical composition (nitrites, nitrates, and hydrogen peroxide) in the given PTL (artDC, artAC air ) were tested in parallel to the tested PTLs

Together, these factors compromise overall sperm quality and hinder the fertilization process (64, 65)

The following table provides standardized protocols based on common clinical goals