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This review discusses the biology of GLP-1 and its effects on cardiovascular risk factors, and it also elaborates on the positive direct cardiovascular outcomes of GLP-1 in animal studies

In September 2025, the FDA sent thousands of warning letters and issued approximately 100 cease-and-desist letters to companies regarding their use of misleading direct-to-consumer pharmaceutical advertisements. The agency also published a green list of acceptable GLP-1 compounding ingredients intended to regulate ingredient sourcing and reduce the risk of unsafe compounded products

However, a significant reduction in left atrial volume [mean difference 8.7 mL ( 14.2, 3.2), P = 0.002] and in E/e ratio [mean difference 1.4 ( 2.7, 0.1), P = 0.03] [52] was reported

Adida M, Jollant F, Clark L, Besnier N, Guillaume S, Kaladjian A, et al