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It's worth noting that higher-dose semaglutide for obesity (Wegovy) involves greater weight loss, which could potentially have indirect effects on bone density through mechanisms discussed in the next section

How I do it: I pick an area on my stomach, at least two inches away from my belly button

Providers must screen for these conditions before initiation

This should be regarded as a major evidence gap and a priority for future longitudinal studies

Choose phentermine if you: Need a lower-cost appetite tool with fast impact Prefer a tablet over injections Want a short-term reset with coaching and accountability Consider GLP-1s if you: Aim for larger total body-weight loss and can tolerate injections or oral GLP-1 dosing Have metabolic comorbidities where GLP-1 therapy provides additional benefits Have coverage/savings that reduce out-of-pocket cost Are willing to make a permanent financial commitment, as all studies show a very high rate of weight regain when stopping GLP-1s