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Scheen AJ, Delanaye P

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Notably, even after stopping the drug, some weight loss benefit persisted long-term, albeit much weaker than with continued treatment

Significant barriers still exist despite established safety profiles, such as high costs that restrict access worldwide, a lack of predictive biomarkers for treatment response, a lack of knowledge about the mechanistics of gut microbiota interactions, and an incomplete understanding of long-term safety, particularly with regard to thyroid and pancreatic effects