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Thiamine deficiency disorders: a clinical perspective

A variety of cellular stresses, including DNA damage can cause the induction of cellular senescence, which represents a multifaceted and highly heterogeneous cellular state characterized by irreversible growth arrest and importantly the secretion of a multitude of factors, including proteases and chemokines 2

Melagraki, Georgia, Evangelos Ntougkos, Vagelis Rinotas, Christos Papaneophytou, Georgios Leonis, Thomas Mavromoustakos, George Kontopidis, Eleni Douni, Antreas Afantitis, and George Kollias

L., Miniard, A

For patients with valproic acid poisoning and hyperammonemia, some additional therapies directed at this component of the intoxication might be beneficial