how long are most people on glp 1 starting GLP-1s expect the weight to just fall off — but the real data tells a more nuanced story. Studies show average weight loss GLP-1 medications ranges from 5% GLP-1 use peaks in middle

The central application of GLP-1 receptor agonists potently decreases food intake, likely through GLP-1 receptor (GLP-1R)-expressing targets in multiple brain areas including in the hypothalamus and brainstem (24, 26, 28-30), nuclei also targeted by estrogen (31), supporting a potential interaction

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Focus on resistance training to preserve muscle during weight loss

Use protein shakes if whole food protein difficult during nausea weeks

They found that, as first-line agents, SGLT2is and GLP-1RAs would improve T2DM outcomes, but their costs would need to fall by at least 70% to be cost-effective [84]