As a class effect observed with GLP-1 receptor agonists, there are precautionary concerns based on animal studies regarding thyroid C-cell tumours
Many insurance companies require evidence that you have tried and failed other weight loss methods before approving GLP-1 coverage
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This GPCR is primarily expressed in the pancreas by -cells, -cells and -cells (271, 318, 319), and is found at lower concentrations along the GI tract, especially in the stomach and duodenum, where counterintuitively only a minor fraction of CCK, and GLP-1 expressing duodenal enteroendocrine cells display GPR119 (266, 271)
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