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As both High and Low WL responders were consuming the same diet, our results suggest differences in GM composition and metabolism, which could play a role in determining the success of an IF-P regimen

To achieve GSH depletion in liver, we engineered an adeno-associated virus (AAV) vector encoding Chac1 fused to a Myc tag, driven by the thyroxine-binding globulin (TBG) promoter to achieve liver-specific overexpression of Chac1 (Figure 1B)

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