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More details here: medicalxpress.com/news/2026-04-a And full paper published in Nature: nature.com/articles/s4436 Concerning because of how gameable it just became

These mimic the action of the natural GLP-1 hormone in such a way: G activates adenylyl cyclase (AC), increases cAMP, activates protein kinases (PKA), and results in more calcium (Ca) in the cytosol

While some doctors have anecdotally reported similarly positive experiences in their patients who switched to a slower schedule, the studys results are limited: The sample size is quite small, for one, and more work in larger and more diverse groups will be needed to understand if different dosing schedules could help more people stay on their medication, without getting the pukes.

Mayo Clinic Proceedings, 92 (1), 114128