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Proper disposal protects more than people: environmental contamination from improperly discarded sharps can leach into groundwater and harm aquatic ecosystems

In humans there have been mutations identified in prohormone convertase 1/3 (PC1/3) and carboxypeptidase E (CPE), as well as in the -MSH degrading enzyme prolylcarboxypeptidase (PRCP) that are associated with energy imbalance and a propensity for obesity

Kit A, Conway K, Makarowski S, ORegan G, Allen J, Shultz SR, et al

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Indeed, an estimated 80% of the population in one study experienced GI-related AEs compared with 46% for placebo