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Crossing these Jnk1 LoxP/LoxP / Jnk2 -/- mice with Alb-Cre mice produced Jnk hepa ( Jnk hepa mice developed higher liver injury than wild-type animals after APAP overdose, suggesting a beneficial role for combined Jnk1 and Jnk2 activation in hepatocytes during APAP-induced hepatotoxicity

Corpas FJ, Palma JM

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Specifically, preclinical studies tend to batch collect and process samples, whereas clinical studies tend to collect and process samples one at a time

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