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In addition to the central source, peripheral GLP-1 is released from enteroendocrine L-cells in intestinal mucosa (Eissele et al., 1992) which plays an important role in regulating glucose homeostasis (Edwards et al., 1999

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Although activation of the GLP-1 receptor primarily facilitates weight reduction through appetite suppression, the inclusion of GIP receptor agonism offers supplementary and synergistic advantages, including improved insulin sensitivity and overall metabolic health