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Tirzepatide has a dual-hormone approach (GLP-1 and GIP), which may offer even greater weight loss

This causes an increased paracellular permeability, modulation of transcytosis, and endocytotic transport mechanisms, leading to changes in transcellular transport and inflammatory damage in the brain parenchyma (Sweeney et al., 2019)

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Sarnelli G, Pesce M, Barbara G, de Bortoli N, Sario AD, Esposito G, Frazzoni M, Galloro G, Gatta L, Ghisa M, Londoni C, Marabotto E, Meggio A, Pisani A, Ribolsi M, Usai Satta P, Savarino V, Scarpignato C, Stanghellini V, Tosetti C, Visaggi P, Zingone F, Barberio B, Savarino EV (2025) Italian guidelines for the diagnosis and treatment of functional dyspepsiajoint consensus from the Italian societies of gastroenterology and endoscopy (SIGE), neurogastroenterology and motility (SINGEM), hospital gastroenterologists and endoscopists (AIGO), digestive endoscopy (SIED) and general medicine (SIMG)