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Most critically, while the mechanistic and preclinical foundation is strong, clinical studies in humans would be required to establish optimal dosing, administration schedules, safety profiles, and actual synergistic effects for this specific combination

PMID: 35926641

Moreover, intracellular staining for IL-5 and IL-13 ( Supplementary Figures 4HI ), corroborated with our previous findings that melatonin ILC2s produced less cytokine than vehicle treated controls ( Supplementary Figures 4BF, H, I )

It's another possible mechanism for affecting metabolism

Using sterile water without a preservative is an invitation for contamination, which can completely invalidate your research findings