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Wiley Encyclopedia of Clinical Trials

In the case of GSTs, these multifunctional and essential enzymes are involved in many processes, such as detoxification, signaling, redox homeostasis, plant metabolism, growth regulation, and adaptation to biotic and abiotic stress (Sabetta et al., 2017)

The link between GSTs and the MAP kinase pathway provides a rationale as to why in many cases the drugs used to select for resistance are neither subject to conjugation with GSH, nor substrates for GSTs