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This is dependent upon both your genetics and your environment - those who smoke, laugh or smile more frequently, or who dont protect themselves from the sun, will experience them earlier in life than if they had not had these negative environmental factors

User experimentation suggests that longer initial treatment periods (6+ months continuous) support better benefit retention during subsequent breaks, complete discontinuation breaks of 1-2 months show acceptable benefit maintenance for most users, and very extended breaks (3-6+ months) increase risk of regression toward pre-treatment baseline particularly for short initial treatment courses

Awosemo, O

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