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Gut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion

Several retrospective analyses and smaller studies suggested that GLP-1 based therapies decreased cravings and dampened the reinforcing effects of addictive substances, in particular alcohol, where most of the data is available at the moment

This growth is primarily driven by the increasing prevalence of diabetes, rising healthcare expenditure, and rapid uptake of GLP?1 receptor agonists and SGLT?2 inhibitors alongside established oral antidiabetics and insulins

This contributes to a healthier relationship with food and supports lasting weight management