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Notably, these studies are still mostly based on cellular or animal models with unvalidated clinical translatability, and the cross-validation of ferroptosis regulatory mechanisms remains insufficient

However, some cutting-edge technologies like PROTACs (proteolysis-targeting chimeras), RNA interference, clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-based genome editing, and artificial intelligence (AI)-based drug design, allow screening of therapeutics targeting almost all kinds of molecules, like proteins and epigenetic regulators

Epithalon (also known as Epitalon ) is a synthetic tetrapeptide used in laboratory research to study telomere biology, peptide signaling, and related cellular pathways in controlled experimental systems

The exposure to this pH causes a gradual dissolution of the surface ions of the biomimetic mineral crystalline lattice, with a consequent controlled in vivo delivery of glutathione and cysteine

Disrupting the phosphatidylinositol (PI) 3-kinase VPS34 ( CPAR2_206880 ) also induced hypersensitivity to oxidative and cell wall stresses, copper and cadmium, and azoles (Fig