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One remaining challenge is relating these structural transitions in a precise way to changes in catalytic rates

119 Conversely, at the N-terminal domain, a non-catalytic regulatory haem sensor negatively impacts the enzymatic activity of CBS upon reduction and completely inactivates the enzyme upon binding of nitric oxide or carbon monoxide

The cells were treated with these cocktails for 3 days, with variations in CHIR concentration and the presence of Ly or PD to optimize DE induction efficiency [1]