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Fortunately, there are ways to manage and even prevent it: Eat small, frequent meals instead of large ones

The PIONEER 1-8 clinical studies show that 1.7 to 12% of patients discontinued Rybelsus treatment due to side effects, with gastrointestinal side effects being the most common

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[ref] Healing myocardial injury: Keeping the heart muscle healthy is important, of course

If a patient has achieved substantial weight loss on tirzepatide but has plateaued, providers might consider whether the modest additional benefit from orlistat justifies the added side effects and cost