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The effect of an increase in AMP inhibits phosphatase activity, and considering that LKB1 is constitutively active [100], the response after a rise in AMP increases the phosphorylation of Thr172 and the activation of AMPK

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Although resveratrol shows promising anti-cancer potential, its efficacy has been limited to tumors with direct contact, such as skin cancers or gastrointestinal tract cancers, rather than human solid tumor cells, due to its poor bioavailability [128]