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Glycaemic regulation models: In hyperglycaemic clamp models and oral glucose tolerance test paradigms in rodents, GLP-1R/GIPR co-activation with concurrent GCGR engagement did not produce the hyperglycaemic signal that might be predicted from glucagon receptor activation alone

Genomics 19 , 201208 (2020)

Suitable candidates typically include adults with a Body Mass Index (BMI) of 30 kg/m or higher, indicating obesity, or those with a BMI of at least 27 kg/m and weight-related health conditions, such as elevated cholesterol levels, hypertension, or type 2 diabetes

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