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The above findings suggest that GPx1 prevents endothelial dysfunction by limiting the damaging effects of excess ROS which preserves bioavailable NO and normal endothelial vasodilator responses

Curr Pharmacol Rep 8 , 262280 (2022)

Pharmacological or gene inhibition of glutathione transporters, including multidrug resistant protein 1, can block cell GSH release, reduce intracellular ROS levels and production of oxidized phosphatidylcholine, thereby inhibiting cell ferroptosis

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The presynaptic nicotinic receptors have a different subunit composition compared to the muscle-type nicotinic receptors