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Understanding how it actually works at a biological level, not just what it is claimed to do, is the foundation for making any responsible clinical decision about whether it belongs in a protocol

The distance between the two IPT2 domains of c-METs in this structure is ~20 , hinting that the two membrane-proximal IPT4 domains of c-METs are likely to be positioned in proximity in this specific dimeric conformation that allows the intracellular KDs to undergo trans -autophosphorylation