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In this episode, TRC Healthcare Associate Editor and Clinical Pharmacist Vickie Danaher, PharmD discusses how semaglutide became the first FDA-approved oral GLP-1 agonist for obesity
The gradual changes are helpful in losing weight
Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted by L-cells in the distal small intestine and colon in response to nutrient ingestion
Retatrutide is used in research settings to examine GLP-1 pathway activity in combination with other receptor systems rather than as an isolated single-target model
This sparked the idea that GLP-1 analogs with enhanced stability could be developed as potential treatments for type 2 diabetes
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