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Some GLP-1 medications, such as semaglutide, act through a single receptor, whereas tirzepatide also acts through GIP
The stability of piroxicam, verapamil and 7-ethoxycoumarin were also determined and utilized as high, moderate and low metabolized controls, respectively
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That observation ultimately reshaped the trajectory of the entire drug class, leading to obesity-specific formulations and, more recently, FDA approvals for additional chronic conditions
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