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To assess the interaction between human Met and the macrocycles, human Met ectodomain-Fc chimera was immobilized to a surface density of 1,2001,600 response units (RUs) on a CM5 sensor chip using a human antibody capture kit (GE Healthcare)

Chappell LC, Duckworth S, Seed PT, Griffin M, Myers J, Mackillop L, Simpson N, Waugh J, Anumba D, Kenny LC, et al

This observation suggests that PNC-27 likely induces necrosis through pore formation in the cell membrane, rather than triggering apoptosis

Kent, J

In addition, transient GLS1 inhibition or lysosomal acidification may induce changes in chromatin accessibility and preservation of epigenetic properties, which may contribute to the long-term persistence of CD8 + T cells in tumors(Madden et al