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Noteworthy, the association of GLP-1RAs and SGLT-2is is representing a new pharmacological opportunity opening an innovative scenario with potential additive pleiotropic effects that will require further studies

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Dose-dependent accumulation of glucose in the intestinal wall and lumen induced by metformin as revealed by 18 F-labelled fluorodeoxyglucose positron emission tomography-MRI

IGF-1 LR3 stabilizes blood glucose The two substances in the human body responsible for maintaining stable blood sugar levels are insulin and IGF-1