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EGR and MITF binding motifs, previously shown to be enriched after BDG exposure in this dataset (36), was enriched in all the groups with the highest levels of enrichment in clusters with increased chromatin accessibility (A-C) and cluster F

Particularly, Lip-1 treatment decreased the abundance of adora2a transcript among the hypoxia-associated adenosinergic system (Figure 2A), which was also confirmed by quantitative reverse transcriptase PCR (qRT-PCR) (Figure 2B)

The proposed mechanisms range from well-validated (FDA-approved GLP-1 agonists for weight loss) to highly speculative (epitalon, thymosin alpha-1, MOTS-c) with limited or no human clinical validation

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