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While GLP-1 drugs like semaglutide or tirzepatide boost insulin secretion and reduce glucagon, cagrilintide primarily slows gastric emptying and suppresses appetite via amylin receptors

The structural element necessary for binding to the L-type calcium channel is the NH group of the DHP ring, which forms a hydrogen bridge with glutamine (Gln-1060)

References Albrecht S, Jung S, Mller R, et al

Contact your GP promptly if you experience sudden swelling of the ankles or legs, facial swelling, swelling with shortness of breath, rapid unexplained weight gain, or reduced urine output

Fatty proteins, meaning fatty cuts of red meat, pork belly, or high-fat fish, take longer to digest and can worsen the fullness and nausea that GLP-1 users already experience