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Less common but important effects include pancreatitis risk in susceptible individuals, gallbladder issues, and very rare reports of thyroid or retinal complications

We hypothesized a chain of events in which Rot impairs mitochondrial energy metabolism by inhibiting CI, disrupting mitochondrial homeostasis (mitostasis), which encompasses mitochondrial function, distribution, and quality, and is essential for neuronal health due to their high metabolic demands 28

Major sites of SULT2A1 expression are the liver, adrenal gland, ovary, and duodenum (Javitt et al., 2001)

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1 Safety: The overall safety profile of tirzepatide in SURMOUNT-5 was similar to previously reported SURMOUNT trials