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Visceral belly fat produces estrone, a weak form of estrogen that can fuel estrogen dominance
If any part of this signaling chain is disrupted by inflammation, oxidative stress, or nutrient depletion, the cells become "deaf" to insulin's signala state known as insulin resistance
In our mGluR1 driven melanoma model, we have demonstrated that mGluR1 + melanoma exosomes when taken up by mGluR1 recipient cells promote these cells to become more migratory, invasive and develop an anchorage-independent growth phenotype compared to mGluR1 melanoma exosomes (114)
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